Chelation in experimental Pseudomonas keratitis.
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چکیده
منابع مشابه
Chelation in experimental Pseudomonas keratitis.
In cohtrast to its occasional occurrence during the first half of the 20th century (Joy, I942), Pseudomonas aeruginosa to-day ranks as a common, if not the most common, cause of bacterial corneal ulcer in the United States of America. Even with prompt laboratory diagnosis and use of adequate and specific antimicrobial therapy, the rapidly destructive lesion caused by this bacterium frequently r...
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The role of mucin in the manifestation of Pseudomonas keratitis was studied. Pseudomonas was cultivated in solutions of mucin, in which it grew rapidly and then inoculated into rabbit cornea by needle pricks. When the organism was inoculated as a suspension in saline, infection infrequently occurred as small ring abscesses of short duration around a few sites of inoculation. When the organism w...
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When the ocular toxicity and the in vivo and in vitro effects of gentamicin, Nebcin, and saline solution were compared in experimentally induced Pseudomonas keratitis in rabbits, both antibiotics showed the same toxicity for the rabbits' conjunctival tissues. But Nebcin showed better in vitro and in vivo results than gentamicin, and the clinical effect was confirmed by culture study: significan...
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In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea. The use of these drugs in combination had an additive effect in vitro studies and a significantly more beneficial effect on the clinical disease than the use of ...
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Pseudomonas aeruginosa is one of the most virulent and frequently encountered infectious agents affecting the cornea (Allen and Mangiaracine, 1964). Unhappily, its destructive effect on ocular tissues cannot always be prevented by the antibiotics currently available. The best anti-Pseudmonas drugs are colistin, polymyxin B, and gentamicin (Burns, 1969; Gordon, 1970), but Pseudomonas strain-resi...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1970
ISSN: 0007-1161
DOI: 10.1136/bjo.54.9.587